Solid Phase oligonucleotide synthesis is the chemical synthesis of relatively short fragments of nucleic acids with defined chemical structure (sequence). It's a classic technique which is extremely useful in current laboratory practice because it provides a rapid and inexpensive access to custom-made oligonucleotides of the desired sequence. The traditional solid phase oligonucleotide synthesis consumables use two frits and CPG powder between the frits.

Developed since 2014, Biocomma Embed ™ technology represents a breakthrough in efficient, expedited, and cost-effective oligonucleotide synthesis. Our Embed™ seamlessly blends PE powder and CPG powder before placing them into a mold where they are heated to a high temperature, reaching a molten state. This unique process sinterizes the PE and CPG materials together, creating a sponge-like porous structure cylinder known as a CPG frit. By adjusting the size of the PE particles, we can precisely control the pore size of the frits. This allows us to control the flow rate.